to make someone feel tired and less able to deal successfully with a situation

Both sides are trying to wear the other down by being obstinate in the negotiations. 双方在谈判中都不肯让步，试图耗尽对方的耐性。

All the stress and extra travel is beginning to wear him down. 所有那一切压力和加班出差开始使他筋疲力尽。