the stage at which it is no longer possible to stop what you are doing and when its effects cannot now be avoided or prevented

Russia, he said, had reached the point of no return on the road to reform and had to go forward. 他说道，俄罗斯在改革的道路上已经再无退路了，必须向前走。

Scientists fear that global warming has gone beyond the point of no return. 科学家们担心全球变暖已经到了无法遏制的阶段。