unable to behave or deal with things normally because something has made you very worried, unhappy, or angry

She was out of her mind with grief. 她因悲伤而精神错乱。

I'd go out of my mind if I had to do her job all day! 要是让我整天做她的工作，我会发疯的！

extremely stupid or mentally ill

You must be out of your mind paying £500 for one night in a hotel! 花500英镑在酒店住一晚，你一定是发疯了！